Baseline characteristics of participants stratified by PhenoAgeAccel categories

Association results of PhenoAgeAccel with site-specific cancer risk per 5 years increased.

Cox proportional hazards regression adjusted for age, height, cancer family history, Townsend deprivation index at recruitment, and the first 10 principal components of ancestry.

Effect of PhenoAgeAccel on the risk of incident cancer in the UK Biobank.

The distrubution of PhenoAgeAccel between participants with incident cancer and those without incident cancer in the UK Biobank for men(A) and women (B). Participants in the UK Biobank were divided into ten equal groups according to the PhenoAgeAccel for men (C) and women (D), and the hazard ratios (HRs) of each group were compared with those in the bottom decile of PhenoAgeAccel. Error bars are 95% CIs. Standardized rates of cancer events in younger and older PhenoAge groups in the UK Biobank for men (E) and women (F). HRs and 95% CIs were estimated using Cox proportional hazard models with adjustment for age, height, family history of cancer, Townsend deprivation index, and the first 10 principal components of ancestry. Shaded areas are 95% CIs.

Association between P henoAgeAccel and cancer risk

Risk of incident cancer according to genetic and PhenoAgeAccel categories in the UK Biobank for men (A) and women (B).

The HRs were estimated using Cox proportional hazard models with adjustment for age, height, family history of cancer, Townsend deprivation index, and the first 10 principal components of ancestry. Participants were divided into younger and older PhenoAge under different genetic risk groups.

Risk of incident cancer according to PhenoAgeAccel categories within each genetic risk levela

Absolute risk estimates of overall cancer based on the UK Biobank for men (A) and women (B).

The x-axis is chronological age. The curves describe average risk of participants in younger and older PhenoAge groups. The dashed curve represents the average risk of the whole population in different ages. The red horizontal dotted line represents 2% of 5-year absolute risks of overall cancer.