Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.
Jean-David Larouche, Céline M Laumont ... Claude Perreault
Multiomic analyses provide new insights into the involvement of transposable elements in T-cell development in the thymus and central tolerance induction.
Toyoshi Yanagihara, Kentaro Hata ... Isamu Okamoto
Increased CD16+ T cell populations in bronchoalveolar lavage fluid highlight a potential biomarker and immune response mechanism in Pneumocystis jirovecii pneumonia.