Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Vascular Endothelium: More than just a simple barrier

    Erandi Velazquez-Miranda, Ming He
    Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Genetics and Genomics

    Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production

    Nina K Jain, Pierce J Ogden, George M Church
    Measurement of the effect of all single-codon variants of the AAV2 rep gene on recombinant adeno-associated virus production identifies novel beneficial variants, which may facilitate improvement of gene therapy production.
    1. Developmental Biology
    2. Genetics and Genomics

    Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

    Zian Liao, Suni Tang ... Martin Matzuk
    Mouse models reveal fundamental roles of SMAD1/5 in mediating both bone morphogenetic protein signaling pathways and the transcriptional response to progesterone during decidualization.
    1. Genetics and Genomics
    2. Neuroscience

    Sibling chimerism among microglia in marmosets

    Ricardo C.H. del Rosario, Fenna M. Krienen ... Steven A. McCarroll
    1. Genetics and Genomics
    2. Evolutionary Biology

    Epistasis facilitates functional evolution in an ancient transcription factor

    Brian P.H. Metzger, Yeonwoo Park ... Joseph W. Thornton

Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Alan Moses
    University of Toronto, Canada
  4. See more editors