Structural Biology and Molecular Biophysics

Latest articles

1. 1. Structural Biology and Molecular Biophysics

   Divergent Folding-Mediated Epistasis Among Unstable Membrane Protein Variants

   Laura M. Chamness, Charles P. Kuntz ... Jonathan P. Schlebach
2. 1. Structural Biology and Molecular Biophysics

   Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies

   Christian Galicia, Giambattista Guaitoli ... Wim Versées

   Conformation-specific nanobodies enable to capture and solve the first GTP-bound active structure of a bacterial homolog of the Parkinson-associated LRRK2 protein, providing insights into the activation mechanism of these proteins.
3. 1. Developmental Biology
   2. Structural Biology and Molecular Biophysics

   Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

   Arne Elofsson, Ling Han ... Luca Jovine

   AlphaFold-Multimer was used to investigate extracellular protein interactions involved in mammalian egg-sperm recognition, suggesting a putative pentameric complex that includes TMEM81, a sperm protein not previously involved in gamete recognition.
4. 1. Structural Biology and Molecular Biophysics

   Dependence of nucleosome mechanical stability on DNA mismatches

   Thuy TM Ngo, Bailey Liu ... Taekjip Ha

   The mechanical stability of a nucleosome is enhanced upon the introduction of a single base pair mismatch that makes DNA more bendable, with implications on mismatch repair in vivo.
5. 1. Cell Biology
   2. Structural Biology and Molecular Biophysics

   PURA syndrome-causing mutations impair PUR-domain integrity and affect P-body association

   Marcel Proske, Robert Janowski ... Dierk Niessing

   Structural promiscuity in PURA protein, induced by patient mutations, impacts nucleic acid binding, unwinding, and subcellular localization, indicating why so many patients display the full disease spectrum of PURA syndrome.
6. 1. Microbiology and Infectious Disease
   2. Structural Biology and Molecular Biophysics

   Molecular mechanism of complement inhibition by the trypanosome receptor ISG65

   Alexander D Cook, Mark Carrington, Matthew K Higgins

   A structure derived from cryogenic electron microscopy shows how ISG65, an African trypanosome receptor that aids virulence, binds C3b and suggests mechanisms through which ISG65 might aid complement resistance.
7. 1. Structural Biology and Molecular Biophysics

   LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

   Colin H Peters, Rohit K Singh ... John R Bankston

   A combination of patch clamp electrophysiology and FRET determine critical interactions between HCN4 channels and the ER resident protein LRMP and suggest a possible mechanism for reduced cAMP sensitivity.
8. 1. Structural Biology and Molecular Biophysics

   N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine

   Chuchu Wang, Chunyu Zhao ... Cong Liu
9. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

   Sandeep K. Ravala, Sendi Rafael Adame-Garcia ... John J. G. Tesmer
10. 1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    X-ray structure and enzymatic study of a bacterial NADPH oxidase highlight the activation mechanism of eukaryotic NOX

    Isabelle Petit-Hartlein, Annelise Vermot ... Franck Fieschi

    Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.